预先暴露低强度噪声对噪声损伤听力保护作用的观察.pdfVIP

维普资讯 预先暴露低强度噪声对噪声 损伤听力保护作用的观察 阮芳铭 膏文元 (第=军医大学海医系舰艇卫生学教研室) 强噪声暴露可致听 力捐伤 ，产生暂时性或永久性听 闺偏移 。听 力损伤程度除和 噪声暴露参数有关外，还和听觉系统奉身的生理和代谢状态有关(1) 实验证实，外 毛细胞在声刺激后有类似耳肌收缩样作用[2)，但这种收缩作用对听 力的生物效应还 不清楚。低强度无损害性噪声暴露对后来的强声刺激是否有保护作用，国内尚未见 有报早。本实验 以豚 鼠为实验动物 ，预先暴露低剂量安全噪声，随后暴露能产生听 觉损害的强噪声，观察前者对后者 的听 力损伤有无保护作用。 ^N INVESTIGATION OF PROTECTIVE EFFECT 0F PRE-EXPOSURE TO LOW LEV口 NOISE ON NOISE INDUCED HETd~ING DAMAG~ Ruan Fangming。Gao wenyuan Dept．of Naval Medicine，The Second Milltary Medical 。 College．Shanghai 200433，Chins Abstract ： The protection against noise trauma hy pre- exposure to low noi8e waB investigated·19 guinea Pigs divm ed into test(n=9】and contro1 【n=1O)group，were used as subJeots．The animals of the test group were pre- expoeedto9OdBSPLwhitenoise (2h／d)for 1Odays tthen were expo8ed to 110 dI]SPL white noi8e for 30 min．The Control group was exposed to 110 dB white noise for 30 min on1Y 日nd not Pre-expcsed to 上ow 1eve no1se · Theresults showed that (1)．The threshold shifts of tne test grouP produced by the 上ow 1eve1 noise were dlm1一 nished with the expcs!ng days． i．e． the threshold shift8 at the 8econd day were 12 dB whi1e at the five and a七 七he tenth day were 了dB and5 dB re8peetive1y． (2)．The thresh- c1d shiits of the test grouP produced by the high ievel noise were mush smaller than tha七 of the control group betwsen O．5 to 48h post exPo8ure． There ws8 significant J ■ 1 differenee between the two groups． It is c1ear that pre— exposure to low level noise ameliorated the damaging effect8 of a second intensiv