KISS1GPR54基因及其在生殖中的作用.pdfVIP

HEREDITAS (Beijing) 2008 4 , 30(4): 419―425 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2008.00419 KISS-1/GPR54 1 2 1 冯涛 , 储明星 , 张英杰 1. , 730070; 2. , , 100094 : KISS-1 及其受体 GPR54 基因对青春期的正常启动具有重要作用。青春期开始前后, 动物下丘脑中KISS-1 和GPR54 mRNA 水平很高, Kisspeptins(KISS-1 基因产物)通过激活GPR54 增加促性腺激素的释放, KISS-1 基因 的表达受性腺类固醇激素的调控。GPR54 基因突变可以导致人和鼠的特发性促性腺激素分泌不足性腺机能减退 症和促性腺激素依赖性性早熟。文章还介绍了 KISS-1 、GPR54 基因的结构、表达、多态性以及和其它生殖调 控因子之间的相互关系。 : KISS-1 基因; GPR54 基因; Kisspeptin; 生殖; 调控 KISS-1/GPR54 genes and their role in reproduction 1 2 1 FENG Tao , CHU Ming-Xing , ZHANG Ying-Jie 1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China; 2. The Key Laboratory of Domestic Animal Genetic Resources and Germplasm Innovation of CAAS, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100094, China Abstract: KISS-1 gene and its receptor gene GPR54 play key roles in the initiation of puberty onset. The peptide product of the KiSS-1 gene, Kisspeptins stimulate gonadotrophins release to initiate puberty through the expression of GPR54 gene in the brain. So the level of KISS-1 and GPR54 mRNA in hypothalamus was very high on the onset of puberty. The expression of KISS-1gene was regulated by steroid hormone in different nuclei within the forebrain to control the reproduction in pu- berty. Loss of function mutations of GPR54 gene could cause idiopathic hypogonadotropic hypogonadism (IHH) and go- nadotrophin-dependant premature puberty. This review also introduced the structure, expression, homology comparison, polymorphism of KISS-1 and GPR54 genes and their interrelation with other regulators of reproduction.