Ki_67和P21在肾上腺皮质癌中的表达及意义.pdfVIP

2004 12 2 1 12 J Clin Intern Med, December 2004, Vol, 21, No. 12 # 849 # ## K-i 67 P21 欧阳金芝 周国保 张旭 马鑫 郑涛 李宏召 [ ] R736. 6 [ ] A [ ] 100 1-9057( 2004) 12-0849-03 [ ] ( ACC) K-i 67 P21 SP 8 20 ( A CA) 19 K-i 67P21 K-i 67 P2 1 (P 0. 01, P 0. 05) K-i 67 2 ( P 0. 01) , ( P 0. 05) P21 2 ( P 0. 05) K-i 67 P2 1 , K-i 67 [ ] ; K-i 67; P21; The expression of Ki-67 and P21 in adrenocortical carcinoma and their significance O UYA N G * * Jinz hi , ZH O U Guobao, ZHA N G X u , et al . Dep artment of Endo r inology , Dep art ment of Urology , Tongj i H osp ital , Tongj i M edi al College, H uaz hong University of S ien e and Te hnology , Wuhan 430030, Chin [Abstract] Objective T o study the expression of K-i 67 nd P21 in drenocortic l c rcinom nd t heir signific nce. Methods K-i 67 nd P21 were detected by immunohistochemic l technique ( SP method) nd im ge n lysis in 8 c ses of norm l dren l, 20 c ses of drenocort ic l denom ( A CA) nd 19 c ses of drenocortic l c rcinom ( ACC) . Results There w s st tistic lly signific nt difference in ex- pressions of K-i 67 nd P21 mong norm l dren l, drenocortic l denom nd drenocortic l c rcinom ( P 0. 01, P 0. 05) . There w s signific nt correl tion betw een K-i 67 expression nd tumor st ge, inv - sion, met st sis, surviv l r te of 2 ye rs (P 0. 01) . But there w s no rel tionship between K-i 67 expres- sion nd tumor di meter ( P 0. 05) . There w s no signific nt correl t ion between P21 expression nd tumor di meter , st ge, inv sion, met st sis, surviv l r te of 2 ye rs ( P 0. 05) . Conclusions Immuno- histochemic l ssessment of Ki-67 nd p21 c n be useful in the differenti l di gnosis of drenocortic l de- nom nd c rcinom . K-i 67 m