Prohibitin_肿瘤与代谢性疾病治疗的新靶标.pdfVIP

27 5 V ol. 27 N o. 5 2007 10 In ternat ional Journal of P ath ology and C lin icalM ed icine O ct. 2007 Prohib itin 1 2 1 郭东升 , 钱令嘉 , 袁聚祥 1. 华北煤炭医学院预防医学系, 河北唐山 063000; 2. 军事医学科学院卫生学与环境医学研究所应激医学实验室, 天津 300050 ) [ ] Proh ib itin PH B) 是一种高度保守分布广泛的蛋白质PHB 不仅是一类新型的分子伴 蛋白, 而且 参与调节细胞周期维持线粒体结构和功能, 具有抗细胞凋亡衰老和增殖的作用PHB 的多种功能和不同定位, 以及在多种疾病中存在表达差异的现象提示, PH B 可能参与疾病的发生与发展过程因此, PH B在多种疾病如: 肿 瘤糖尿病和肥胖等的治疗方面将会成为有用的药物靶标 [ ] proh ib itin; 肿瘤; 代谢性疾病; 治疗 [ ] R 587. 1; R5 89 [] A [] 2007) Proh ib itin as a novelm olecu lar target for th e th erapy of tum or and m etabolic diseases 1 2 1 GUO Dongsheng , Q IAN L ingjia , YUAN Jux iang ( 1. Dep artm ent of PreventionM edicine, N orth CoalM edicine University, TangshanH ebei 063000; 2. Departm ent of tressM edicine, Institute of H ealth E nvironmentalM edicine, Tianj in 300050, Ch ina) [ Ab stract] P roh ib itin PHB ) is a h ighly conserved and ub iqu itou sly d istributed pro tein invo lv ing in the key bio log ica l processes o f cell cycle regu lation, cell signaling m ed iation, aging, apop tosis, pro lif eration, tum or suppression and m a intenance o f m itochondrial structure and funct ion and so on. T he di verse array of functions and different locat ions of PH B, together w ith the phenom enon of the d ifferent ia l expression in a m yriad of d isease