PTTG和FGF2表达与前列腺癌骨转移的关系研究.pdfVIP

World of TraditionalandWestern ·476· 世界巾西医结合杂志2008年第3卷第8期 JournalIntegrated Medicine2008，VoI．3，No．8 PTTG和FGF2表达与前列腺癌骨转移 的关系研究． 王智勇1。王霞2吕斌3 关系。方法：37例PCa患者，分为无转移组和骨转移组，采用免疫组织化学链霉亲合素一生物素一过氧化物酶复合物 的骨转移过程中发挥重要作用，且二者具有协同作用。 【关键词】前列腺癌肿瘤转移；骨；垂体肿瘤转化基因；成纤维细胞生长因子 【中图分类号】R737．25 【文献标识码】A on of ofPTTGandFGF2with StudyRelationshipExpressions 0sseousMetastasisofProstaticCarcinoma WANG Bin3 Zhi-yong’，WANGXiaz，LV (J．肌，脚LuoyangOrthopedics—TraumatologyHospital，LuoyangHenan471002；2．LuoyangXiehe InstituteFoodand Henan 450003) 471000；3．Henanfor DrugControl，Zhengzhou the ofthe of tumor 【Abstract】Objective：Toinvestigaterelationshipexpressionspituitarytransforming factor withosseousmetastasisof PCa weredi- (fibroblast 2)FGF2 carcinoma(PCa)．Methods：37 growth prostatic patients free ofVITGandFGF2incarcinoma videdintometastasis andOSSEOUSmetastasis group group．Theexpressions specimens of in were weredetectedIHC-SABC mGandFGF2osseousmetastasis by method．Results：Theexpressions grouphigher thanthoseinmetastasisfree differencesin ofPTYGwasrelevant group，indicatingsignificant comparison．Theexpression withthatofFGF2． andFGF2 an and roleinthe of Conclusion：PTrG cooperative expressionsmayplayimportant process metastasisofPca． osseous 【Keywords】Prostaticcarcinoma；osseousmetastasis；PTrG；FGF2 tumor