S1联合顺铂对比S1单药治疗晚期胃癌的临床研究(SPIRITS研究)一项Ⅲ期临床试验.pdfVIP

Articles S-1 plus cisplatin versus S-1 alone for fi rst-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial Wasaburo Koizumi, Hiroyuki Narahara, Takuo Hara, Akinori Takagane, Toshikazu Akiya, Masakazu Takagi, Kosei Miyashita, Takashi Nishizaki, Osamu Kobayashi, Wataru Takiyama, Yasushi Toh, Takashi Nagaie, Seiichi Takagi, Yoshitaka Yamamura, Kimihiko Yanaoka, Hiroyuki Orita, Masahiro Takeuchi Summary Background Phase I/II clinical trials of S-1 plus cisplatin for advanced gastric cancer have yielded good responses and Lancet Oncol 2008; 9: 215–21 the treatment was well tolerated. In this S-1 Plus cisplatin versus S-1 In RCT In the Treatment for Stomach cancer Published Online (SPIRITS) trial, we aimed to verify that overall survival was better in patients with advanced gastric cancer treated February 18, 2008 with S-1 plus cisplatin than with S-1 alone. DOI:10.1016/S1470- 2045(08)70035-4 See Refl ection and Reaction Methods In this phase III trial, chemotherapy-naive patients with advanced gastric cancer were enrolled betweeen page 188 March 26, 2002, and Nov 30, 2004, at 38 centres in Japan, and randomly assigned to S-1 plus cisplatin or S-1 alone.