TLR4及TAK1表达与急性脑梗死炎性反应机制相关性研究_殷建瑞.pdfVIP

现代生物医学 2011 年 第12 卷 第4 期 TLR4 及TAK1 表达与急性脑梗死炎性反应机制相关性研究 殷建瑞，谢富华，解龙昌，高 聪 （广州医学院第二附属医院，广东广州510260） 摘要 目的：探讨急性脑梗死患者外周血中Toll 样受体4 （TLR4）及转化生长因子激活激酶1 （TAK1）表达的变化及其与 炎性反应机制的相关性。方法：对50 例急性脑梗死患者进行临床特征分析、外周血白细胞计数、CRP 水平、NIHSS 评分、 脑梗死灶容积计算及血清TLR4 及TAK1 的含量检测，分析梗死灶容积与上述指标的相关性。结果：急性脑梗死患者血 糖水平、CRP 水平、白细胞计数、NIHSS 评分、梗死灶容积均较健康对照组高，差异比较均有统计学意义（P＜0.05）；急性 脑梗死整个发病过程中血清中TLR4 与TAK1 含量均较健康对照组高，以疾病发病高峰期最明显；脑梗死灶容积与糖尿病 史、CRP 水平、白细胞计数及NIHSS 评分有相关性，其中TLR4 与脑梗死灶容积有独立相关性。结论：TLR4 及TAK1 可能主 要是通过介导炎性反应在脑梗死中发挥作用，其中TLR4 与脑梗死容积有独立相关性，可作为脑梗死的治疗靶点。 关键词 急性脑梗死；TLR4 ；TAK1 中图分类号：R743.3 文献标识码：A 文章编号：1671- 0258（2011）04- 0055- 03 Correlation Between Expression of Toll-like Receptor 4 ，TGF-acti－ vated Kinase 1 and Inflammatory Reaction in Acute Ischemic Stroke Yin Jianrui，Xie Fuhua ，Xie Longchang ，Gao Cong （Department of Neurology ，The Second Affiliated Hospital of Guangzhou Medical University ，Guangzhou Guangdong 510260） Abstract Objective ：To explore expressions of Toll-like receptor 4 （TLR4）and TGF-activated kinase 1 （TAK1）in acute ischemic stroke and their correlation with mechanisms of inflammatory reaction. Methods ：Clinical characters of 50 cases with acute ischemic stroke were analyzed.The counts of WBC in peripheral ，content of CRP、TLR4 and TAK1 in serum were detected ，scoring of NIHSS，volumn of infarct were calculated. Finally ，correlation between volumn of infarct and the above indices was analyzed. Results ：The blood glucose level 、content of CRP、counts of WBC、scoring of NIHSS and vol－ ume of infarct were higher in acute ischemic stroke group than those in control group ；content of TLR4 and TAK1 were in－ creased in acute ischemic stroke group ；volume of infarct was associated with count of WBC ，CRP，scoring of NIHSS and diabetes history ；TLR4 was i