一种dna测序纠错算法6.pdfVIP

ISSN 1000-9825, CODEN RUXUEW E-mail: jos@ Journal of Software, Vol.17, No.2, February 2006, pp .193−199 http://www.j DOI: 10. 1360/jos170193 Tel/Fax : +86-10 © 2006 by Journal of Software. All rights reserved. ∗ 一种DNA 测序纠错算法 + 郑纬民 , 张 华, 王小川 (清华大学 计算机科学与技术系,北京 100084) An Approach to Correcting DNA Sequencing Error + ZHENG Wei-Min , ZHANG Hua, WANG Xiao-Chuan (Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China) + Corresponding author: Phn: +86-10 E-mail: zwm-dcs@, Zheng WM, Zhang H, Wang XC. An approach to correcting DNA sequencing error. Journal of Software, 2006,17(2):193−199. /1000-9825/17/193.htm Abstract: An error correcting algorithm is presented for detecting and correcting errors in the sequencing data before assembly process. The approach maps the sequencing data to an Euler superpath, and simplifies it dynamically by an equivalent transformation named Merging Transformation. In such a process, the algorithm isolates the right edges and error ones so that error paths are substituted and the corresponding errors in the sequencing data are corrected. In two test sets T.tengcongensis and T.whipplei, the algorithm has detected and corrected 86% and 83% errors on the “corrected” sequences respectively, compared with 71% and 53% errors using the original error correcting algorithm in the Eulerian path approach. Key words: error correction; fragment assembly ; DNA sequencing; Eulerian superpath; merging transformation 摘 要: 提出了一种新的测序纠错算法.该算法在对测序数据拼接之前对其进行检查,找出并修正测序序列中 的