冠心病合并2型糖尿病行PCI术前后hsCRP的对比性研究.docVIP

冠心病合并2型糖尿病行PCI术前后hsCRP的对比性研究 　　作者：翟继民，刘传木，张明哲 　作者单位: 257000 山东东营，山东胜利油田中心医院心内科 　　【摘要】 目的 探讨冠心病合并2型糖尿病患者冠脉病变程度与C-反应蛋白（CRP）的关系及经皮冠状动脉介入治 疗（PCI）后的变化。 方法 采用酶联免疫吸附试验（ELISA）测定经皮冠状动脉造影（CAG）确诊并行PCI术的患者及32例 CAG正常者的血清hsCRP水平，并比较不同冠脉病变程度者其血清值及PCI术后的变化。 结果 研究组中的双支及多支 病变组明显高于正常对照组，PCI术后显著高于术前。 结论 血清hsCRP水平与冠心病合并2型糖尿病冠脉病变程度密 切相关。在冠脉粥样硬化的过程中有炎症反应参与，在PCI术后应加强干预。 　　【关键词】 冠心病;糖尿病;C-反应蛋白;经皮冠状动脉介入治疗 　　Contrasted study of serum levels of hsCRP in patients with coronary heart dis- ease and type 2 diabetes before and after PCI 　　ZHAI Ji-min，LIU Chuan-mu，ZHANG Ming-zhe. 　　Department of Cardiology，Shandong Provincial Shengli Oil Field Central Hospital，Dongying 257000，China 　　【Abstract】 Objective To observe the change of C-reactive protein（hsCRP） plasma level before and after percutanous coronary intervention（PCI） in patient with coronary heart disease with type 2 diabetes， to evaluate the relationships between the severity of coronary lesions. Methods 50 patients diagnosed as angina pectoris by coronary angiography received PCI and 32 healthy subjects served as the control.Peripheral blood samples were taken before and after PCI，the serum levels of hsCRP were measured by ELISA.The relationships between serum hsCRP and the severity of coronary lesions were analyzed. Results The mean level of serum hsCRP in the pa- tients were higher than those in the control（ P 0.01），their level in patients with multi-vessel lesions were higher than those in patients with single vessel lesions（ P 0.05） and their levels after PCI were also higher than those before PCI（ P 0.01）. Conclusion The levels of serum hsCRP was associated with the severity of coronary lesions.The inflammation reaction may participate in the progress of coronary lesions. 　　【Key words】 coronary heart disease; diabetes; C-reactive protein;percutanous coronary intervention 　　冠心病合并2型糖尿病的发病机制研究已成为当今心 血管疾病研究的热点之一。有研究表明，血清hsCRP已成 为冠心病