冠心病合并糖尿病人群血清脂联素水平研究.docVIP

冠心病合并糖尿病人群血清脂联素水平研究 　　作者：窦学荣 ，徐红， 王伯松， 闫文菊 ，刘红爱 作者单位：1.泰山疗养院，山东 泰安 271000;2.泰山医学院附属泰安医院心内科，山东 泰安 271000 　　【摘要】 目的 探讨冠心病合并糖尿病人群血清脂联素、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-Α(TNF-Α)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FPG)、空腹胰岛素(FINS)水平并分析其相互之间的关系。方法 以172例临床确诊冠心病(经冠状动脉造影证实)同时合并糖尿病的患者 (B组)为研究对象，67例健康查体者作为对照组(A组) ，对上述指标进行检测。采用Gensini积分系统对冠状动脉狭窄程度进行定量评定。结果 (1) 糖尿病合并冠心病人群血清脂联素水平(6.85±2.71mg/L)明显低于对照组(13.64±3.24mg/L，P0.01)。(2) 血清脂联素水平和hs-CRP、TNF-Α、TG、胰岛素抵抗指数(HOMA-IR)呈负相关，与HDL-C呈正相关。(3)血清脂联素水平与冠状动脉的狭窄程度呈负相关。结论 低脂联素水平是冠状动脉粥样硬化发生及病变程度的重要危险因子;2型糖尿病患者血清脂联素水平的明显下降可作为冠心病的危险因素。 　　【关键词】 冠心病;糖尿病;脂联素;胆固醇;高敏C反应蛋白;肿瘤坏死因子-Α;胰岛素抵抗指数 　　Serum concentration of adiponectin in coronary heart disease patientswith type 2 diabetes mellitus 　　DOU Xue-rong, XU Hong, WANG Bo-song, ZHANG Huan-yi 　　1. Dept.of Cardiology,Taishan Sanatorium of Shandong, P.R 271000 　　2.Depart.of Cardiology, Taian Central Hospital Taian, Taian 271000,China 　　Abstract: Objective: To measure the serum concentration of adiponectin, high sensitive C protein(hs-CRP), tumor necrosis factor-Α(TNF-Α), total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), fasting plasma glucose (FPG), fasting insulin(FINS) in coronary heart disease patients with type 2 diabetes mellitus, and analyse the relationships between them. Methods: The parameters of adiponectin, hs-CRP, TNF-Α,TC,TG, HDL-C, FPG, FINS were measured in 172 coronary heart disease patients(conformed by coronary angiograthy) with type 2 diabetes mellitus(B group) and healthy subjects(A group). Results: The serum concentration of adiponectin(6.85±2.71mg/L) in B group is significantly lower than that of A group(6.85±2.71mg/L, P0.01).(2)The serum concentration of adiponectin is negatively related to hs-CRP,TNF-Α,TG, insulin resistance index, and positively related to HDL-C.(3) The serum concentration of adiponectin is negatively related to extent of coronary artery stenosis. Conclusion: The low level of serum adiponectin is related