双滤过法血浆分离治疗移植肾术后排斥反应及术前高度致敏_陈江华.pdfVIP

·92 · 1999 4 20 2 　Chin J Organ T ransplant, April 1999, Vol.20, No.2 陈江华　王逸民　吴建永　寿张飞　朱丽亚　袁静　朱琮 　　【】　　。　 (DFPP) 36 9 。　24 22 , 10 (ACR), 1, 1 (HAR) ;DFPP 84.0%。8 , 1HAR。　DFPP HAR ACR , 。 【】　/　　　　, Treatment of rejection and highly sensitized in kidney transplantation with double filtration plasmaphere- sis 　CHEN Jianghua, WAN G Y imin, WU Jianyong , et al .K idney Transp lantation and Blood Pu- rif i ation Center, First Af f iliated Hosp ital, Zhej iang Medi al University, Hangzhou 310003 【Abstract】　Objective　To investigate the treatment of rejection an highly sensitize in the renal al- lograft.Methods　Double filtration plasmapheresis (DFPP)w as use to treat 45 patients.Among them, 36 patients, who were resistance to high ose corticosteroi s an antilymphocyte agents, were treate for re- jection, an 9 sensitize patients (50%PRA)un erwent the treatment of removing the antibo y before the ki ney transplantation.Results　Among the 24 cases of acute rejection, 94% rejection crises w ere re- verse by DFPP.The one-year survival rate of the allografte renal in rejection patients receiving DFPP treatment w as 84.0%.Eight sensitize patients of removing the antibo y ha receive renal transplanta- tion.Conclusion 　DFPP was an effective proce ure for the treatment of rejection an for the prevention of hyperacute rejection an ACR me iate by sensitizing antibo y following transplantation. 【Key words】　Ki ney/transplantation　　Rejection　　Therapy, plasmapheresis 　　1994 12 ～1998 9 36 RT )。9 , 4 9 。24 , 21 , 23 ～67 (DFPP), , , 38 。 DFPP 、 2.DFPP :(1)/ , 。 (ALG 、ATG OKT3 ) 3 ～5 ;(2)7 , , 、;(3) 、 , 1.:(A R)24 , ACR ;(4) 21 AR 2 , 1 2 10 , 2 1 ; 。(5)(PRA ) (ACR)10