肠道粘膜免疫系统抗原提呈细胞研究进展.pdfVIP

25 2 20093 # # [ ] 1000-8861(2009)02-0225-04 * 周维英 , 张卫军综述, 邹全明审校 [ ] ,, , , [] ;; [] R392.12 [ ] A Progress in antigen presenting cell in the intestinal ZHOU Weiying, ZHANG Weijun Dep artment of Clinical Microbiology and Clinical Immunology , College of M edical L aboratory , Third Military Medical University , Chong qing 400038, China [Abstract] Antigen presentation is not only a key procedure in immune response but also a complicated interaction and cross-talk be- tween molecules and cells. This articlereviews the new development on antigen presentation and processing pathway in thelocal microenviron- ment of the intestinal immune system, and discusses which cells and molecules participate and promotethe process. [Key words] gastrointestinal tract; mucosal immunity; antigen presentation and processing cell 表 1 结肠粘膜和其它淋巴组织DCs 的分布 , Tab 1 Themain subsets of DCs in intestinal and other lymphoid tissues subset percentage , , lymphoidtissue + + - + - + + - - CD11c CD11b CD8A CD11c CD11b CD8A CD11c CD11b CD8A Peyer. s patches 30- 40 30- 35 30- 35 1 ( professional anti- laminapropria 50- 60 15- 20 15- 20 gen- presenting cell) MLNs 30- 40 30- 35 30-40 1. 1 ( dendritic cells, DCs) 1.1.2 粘膜DCs 活化 DCs , 1.1.1 粘膜DCs 来源与特点 ( MHC , -Peyer. s patches, PP ) ( Lamina Proria, , DCs ) ) ) ,