血清C反应蛋白尿酸和总胆红素水平与冠心病的关系.docVIP

血清C反应蛋白、尿酸和总胆红素水平与冠心病的关系 　　作者：高楠　　作者单位：北京市隆福医院检验科，北京市 　　【摘要】目的：探讨血C反应蛋白(CRP)、血尿酸(UA)和血清总胆红素(TBIL)与冠状动脉疾病的关系。方法：根据WHO冠心病诊断标准，入选冠心病患者148例(CHD组)，非冠心病患者148例(非CHD组)，每组又分为高血脂组和正常血脂组，检测各组患者的血清中CRP、UA和TBIL的水平，观察其与冠心病及血脂的关系。结果：与非CHD组比较，CHD组CRP[(2.69±2.04)mg/L比(6.85±4.76) mg/]、UA[(268±67.83) Μmol/L比(300±76.1) Μmol/L]水平显著升高(P0.01，0.05)，TBIL[(14.8±3.03) Μmol/L比(12.3±3.37) Μmol/L]水平明显降低(P0.05)， CHD组中高血脂组CRP水平明显高于正常血脂组[(8.27±2.56) mg/L比(6.43±1.65) mg/L， P0.01];直线回归分析显示，CRP、UA水平与CHD呈正相关(r=0.91,0.7874 ，P0.05～0.01) ，TBIL水平与CHD呈负相关(r=-0.874， P0.05) 。 结论：C反应蛋白、尿酸水平、总胆红素与冠心病的发生发展密切相关。 　　【关键词】 C反应蛋白质,尿酸,胆红素;冠状动脉疾病 　　Abstract：Objective： To study the relationship among serum levels of C-reactive protein (CRP)， uric acid (UA)， total bilirubin (TBIL) and coronary artery disease. Methods： According to WHO diastolic standard of coronary heart disease (CHD)， a total of 148 CHD patients were enrolled as CHD group， and 148 non-CHD patients were regard as non-CHD group. Each group was further divided into hyperlipidemia sub group and normal blood lipid sub group. Serum levels of CRP， UA and TBIL were measured in all groups， and their relationships with CHD and blood lipid were observed. Results：Compared with non-CHD group， there were significant increase in levels of CRP [(2.69±2.04)mg/L vs. (6.85±4.76) mg/L， P0.01] and UA [(268±67.83) Μmol/L vs. (300±76.1) Μmol/L， P0.05]， and significant decrease in TBIL level [(14.8±3.03) Μmol/L vs. (12.3±3.37) Μmol/L， P0.05] in CHD group， and CRP level in hyperlipidemia sub group of CHD group was significantly higher than that of normal blood lipid sub group [(8.27±2.56) mg/L vs. (6.43±1.65) mg/L， P0.01].Llinear regression analysis indicated that levels of CRP and UA were positively correlated with CHD (r=0.91， 0.7874， P0.05～0.01)， TBIL level was negatively correlated with CHD (r=-0.874， P0.05). Conclusion： Levels of C-reactive protein， uric acid， total bilirubin are closely associated with occurrence and development of coronary heart disease.