静脉注射肝素钠和达肝素钠对血小板激活影响的对比研究.docVIP

静脉注射肝素钠和达肝素钠对血小板激活影响的对比研究 　　作者：郭楠 崔炜 鲁静朝 都军 刘凡 谢瑞芹 杨晓红 谷国强 杨秀春 作者单位：050000 石家庄，河北医科大学第二医院 河北省心脑血管病研究所心内科(郭楠系研究生，现工作单位沧州市中心医院心内科) 　　【摘要】 目的 了解肝素钠(UFH)与低分子肝素(LWMH)对血小板激活的影响有无差别。方法 59例新入院冠心病患者，随机分为UFH组和达肝素钠组，分别于基线状态下、给药(UFH或达肝素钠5000 IU)后30 min、1 h取血，测定CD62P、GP Ⅱb/Ⅲa、血管性假血友病因子(vWF)。结果 UFH组静脉给药后30 min GP Ⅱb/Ⅲa、血浆CD62P及vWF的水平均明显高于给药前(P0.05);给药后1 h GP Ⅱb/Ⅲa及vWF的水平仍显著高于给药前(P0.05);血浆CD62P的水平虽仍较给药前增高，但差异无统计学意义(P0.05)。静脉给予达肝素钠5000 IU 30 min后GP Ⅱb/Ⅲa及血浆CD62P的水平均明显高于给药前(P0.05)，但在给药后1 h即与基线值差异无统计学意义(P0.05);vWF的水平在给予达肝素钠后30 min、1 h均与给药前相比，差异无统计学意义(P0.05)。结论 静脉注射UFH及达肝素钠均可激活血小板;但达肝素钠对血小板活化的影响较小。 　　【关键词】 肝素; 达肝素; 血小板活化 　　Comparison of lowmolecularweight heparin to unfractionated heparin on platelet activation GUO Nan, CUI Wei, LU Jingchao, DU Jun, LIU Fan, XIE Ruiqin, YANG Xiaohong, GU Guoqiang, YANG Xiuchun. Department of Cardiology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China 　　Corresponding author: CUI Wei, Email:cuiwei@ 　　【Abstract】 Objective To compare the platelet activation effect between Dalteparin (lowmolecularweight heparin, LMWH) and unfractionated heparin (UFH). Methods Fiftynine newly admitted patients were enrolled in this study, and were randomly assigned to UFH group or Dalteparin group. Blood samples were obtained through venipuncture so as to measure the plasma CD62P, vWF and platelet membrane GP Ⅱb/Ⅲa at baseline, 30 minutes and 1 hour after UFH (5000 IU) or Dalteparin (5000 antiXa IU) administration. Results UFH group had higher expression of platelet membrane GP Ⅱb/Ⅲa and higher CD62P and vWF levels compared to Dalteparin group at 30 minutes after corresponding drug administration (P0.05). At 1 hour after corresponding drug administrations, no significant differences were found between the two groups with respect to the expression of GP Ⅱb/Ⅲa and plasma CD62P level (all P0.05), while vWF level in UFH group was still significantly higher than that in Dalteparin group (P0.05). Conclusion Both intraven