JAK_STAT6通路的靶向阻断与支气管哮喘治疗的进展.pdf

614 2009 10 36 10 JAK /STAT6通路的靶向阻断与支气管哮喘治疗的进展 * 王乐朋 综述; 王鸿程 审校 : Janus/ ( JAK /STAT 6) ( ) ( IL )-4IL-13 , JAK /STAT 6 : JAK /STAT 6; ; : R56225 : A : 1004-2369( 2009) 10-0614-04 R esearch progress on the treatm ent of bronchia l asthm a w ith interruption in Janus kinase/ Signa l trans- * ducers and activators of transcription 6 WANG L -p ng, WANG H ong-ch ng D partm nt ofR sp irato- * ry M dicin , th Affiliat d H osp ital of Luzhou M d ical Coll g , Luzhou 646000, Ch ina; Corr spond ing au thor Abstract: JAK /STAT 6( Janus k inas / signal transduc rs and activators of transcription 6) is on of th mi por- tant pathw ays in th pathog n sis of bronch ial asthm a( A sthm a) Th stmi ulatory factors in upstr am of th pathw ay, lik int rl uk in( IL)-4, IL-13 tc, ar mi portant factors in th m chan ism of asthm aTh tr atm nt tow ards asthm a by block ing th upstr am signal stmi ulus w ith block ing ag nts m ak s s ns Th articl r - vi w d th r s arch progr ss of th rol s of JAK /STAT 6 in asthma and th targ t int rruption of JAK /STAT6 in th tr atm nt of asthm a K e words: Janus k inas /s ignal transduc rs and activators of transcription 6; T arg t int rruption; B ronch ial asthm a ( Int J Int rn M d, 2009, 36: 614-617) T JH 1-2, JH 3-7 JH4, 18 Janus/ , , JAK ( JAK /STAT6) , C 2, , N JAK [ 2] , JAK [ 1]