维生素B12中依赖酶的环境友好的催化剂.pdfVIP

中国试剂网 2 . 3 . 2 . 2 6 number 138 Contribution Environmental-friendly Catalysts Learned from Vitamin B12-Dependent Enzymes Hisashi Shimakoshi and Yoshio Hisaeda Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka 819-0395, Japan 1. Introduction +1 to +3; Co(I) imparts a gray-green color, Co(II) imparts a yellow-to-orange color, and Co(III), which is the most It is widely known that vitamin B12 derivatives are unique common form, imparts a red color to the B12 derivatives, coenzymes that possess cobalt–carbon (Co–C) bonds and is known as the “red vitamin.” Methylcobalamin and in vivo and are involved in a variety of catalytic functions adenosylcobalamin as the coenzyme forms are parts in combination with various apoproteins.1 Vitamin B12 is of in vivo enzymes that catalyze the biosynthesis of a metal complex in which cobalt ions are coordinated to methionine and the isomerizations with carbon-skeleton 4 ring nitrogen atoms in a corrin ring (Figure 1). It was rearrangements, respectively.3 Recent studies revealed originally developed as a magic bullet for the treatment that the complex of such corrin ring structures acts on the of pernicious anemia, and its unique structure was active center of the dechlorination reaction in anaerobic elucidated by Hodgkin et al. by X-ray crystallography.2 bacteria; this suggests a new function for the B12- The oxidation state of the central cobalt ions range from dependent en