TERC基因对宫颈高级别病变(≥CINⅡ)诊断价值的Meta分析.pdfVIP

TERC基因对宫颈高级别病变(≥CIN¨) 诊断价值的Meta分析 欧亚梦兰 李 力 高 琨+ 广两医科大学附属肿瘤医院妇瘤科(南宁530021) 摘要 目的 系统评价TERC基因对宫颈高级别病变(≥CIN 1／)的诊断价值÷方法计算机检索PubMed、 EMbase、1-heCochrane Library等数据库，检索时间截至2012年3月31日：按照纳入和排除标准筛选文献、提取 资料并根据诊断性试验准确性质量评价工具(QUADAS)评价质量后，采用Meta—Disc1．4软件进行Meta分析：结 果最终纳入12篇文献，共7894例患者：Meta分析结果显示：TERC基因诊断宫颈高级别病变的合并灵敏度、 特异度和诊断比值比分别为o．81[95％CI(o．80，o．82)]、o．83[95％CI(o．82，o．84)]和17．37f95％CI(8．77，34．41)]． 结论TERC基因单独检测宫颈高级别病变的诊断价值中等，可作为临床诊断的一种辅助方法： 关键词TERC基因；宫颈癌；Meta分析；系统评价；诊断性试验 ValueofTERCGeneon Squamous Lesionofthe Diagnostic High—Grade Intraepithelial Cervix：A Meta—Analysis OUYA Kun‘ Li，GAO Meng。lan，Ll Departmentoj Cancer Medical 530021．China GynecologicOncology,AffiliatedHospital啦GuangxiUniversity,Nanning Absteract To evaluatethe valueofTERCon in- Objective systematicallydiagnostic genehigh··gradesquamous thecervix．MethodsSuchdatabasesas TheCochranewere lesion(HGSIL)of PubMed，EMbase，and traepithelial Library searchedMarch totheinclusionandexclusion literaturewas the by 31，2012．According criteria，the screenedand data were extracted．Thewasevaluatedinaccordancewiththe assessmenttoolfor studies quality quality diagnosticaccuracy the wasconductedMeta—Disc1．4software．ResultAtotalof12studies (QUADAS)and meta—analysis byusing involving 7894 caseswereincluded．Theresultsof showedthatthe and oddsratiosof meta·analysis sensitivity．specificitydiagnostic TERConHGSILofcervix 0．80to were O．82to