伊曲康唑白蛋白纳米混悬剂的制备和表征.pdfVIP

中阖兽种夫擎学报 510 JournalofChinaPharmaceutical 2008，39 6 ：510-514 University 伊曲康唑白蛋白纳米混悬剂的制备和表征 张 辉，霍美蓉，周建平’，张志祥 中国药科大学药剂学教研室，南京210009 摘要 目的：制备伊曲康唑白蛋白纳米混悬荆，并对其理化性质及体外溶出行为进行表征。方法：以超声-溶剂沉淀 法制备伊曲康唑白蛋白纳米混悬液及其冻干制剂；利用激光纳米粒度测定仪、透射电镜、差示扫描量热分析仪、x一射线粉末 衍射仪对其形态、结构进行表征；通过透析法研究伊曲康唑白蛋白纳米混悬荆体外溶出行为。结果：伊曲康唑白蛋白纳米 4t”2—8．712 释放符合Higuchi方程 Q 36．9002，r O．9977 。结论：伊曲康唑白蛋白纳米混悬舟】制备方法简便，有望成 为其新型注射给药系统。 关键词伊曲康唑；白蛋白纳米混悬剂；制备；体外释放；表征 中图分类号R944文献标识码A 文章编号1000—5048 2008 06—0510—05 andcharacterizationofitraconazolealbumin Preparation ZHANG Hui，HUO Zhi-xiang Mei—rong，ZHOUJian—ping+，ZHANG Pharmaceutical · DepartmentofPharma虻eutics，ChinaUnwe瑙ity,Nanfing210009，China AbstractAim：To itraeonazolealbumin tocharacterizethe prop- prepare nanosuspensions，and physio-chemical ertiesofitraconazolealbumin andinvitrorelease albumin nanosuspensions methodandcharacterized were ultrasonic—solvent nanosuspensionsby usingdynamiclight prepared disposition electron scattering，Zetapotential，transmissionmicroscopy TEM ，differentialscanning diffraction XRD ．Invitroreleaseofitraeonazolealbumin was X．raypowder nanosuspensionsinvestigated ofitraconazoleinalbumin throughdialysis．Results：Thedrugloading nanosuspensions the meansizeofalbumin before WaS 88．1-4-6．4 ％．The nanosuspensions encapsulationefficiency lyophilization with indexof0．21±0．08．Themeansizeofalbumin after was 105．8±5．2 ampolydisperse nanosuspensions reconstitutionWas1l with indexof0．18±0．09．rIEMshoweda f 8．5±7．4 nmpolydisperse images spherical ofthe initraconazole onDSCandXRD．itWasaftirmedthatitraconazole shape droplets nanosuspensions．Based was inbovineserumalbumin．Itraconazolerelease Writ8 andthatitraconazole amorphous trapped profile伽vitro Wasinaccordancewith 4tⅣ2—8．712 method Higuehiequation Q 36．9002，r 0．9977 ．Conclusion：The describedto itraconazolealbumin iS formulationbeahovelvehicle prepare nanosuspensionssimple．The might for ofitraeonazole． potentiallyinjection words itraconazole；albumin i／／,vitro；characterization Key nanosuspensions；