反流安无糖型混悬颗粒不同制备工艺制剂质量研究.pdfVIP

·86· Chinese Journal of Information on TCM May 2014 Vol.21 No.5 反流安无糖型混悬颗粒不同制备工艺制剂质量研究 1 2 2 1 1 1 金永新 ,郜丽华 ,顾雪艳 ,张瑞堂 ,马肖 ,要林青 1.甘肃省第二人民医院,甘肃 兰州 730000；2.兰州大学,甘肃 兰州 730000 摘要：目的 比较反流安无糖型混悬颗粒不同制备工艺制剂质量,确定最佳制备工艺。方法 对水提、醇 提 2 种工艺按不同制粒配方制备的颗粒色泽、均匀度、味道、气味进行比较,确定浓浸膏-木糖醇-糊精的比例, 并对颗粒的溶化性、粒度、流动性进行考察。分别采用薄层色谱法鉴别 2 种工艺制备的颗粒中的柴胡、白芍、 枳实、延胡索,采用高效液相色谱法测定芍药苷和橙皮苷的含量,对水提和醇提效果进行比较。结果 反流安 无糖型混悬颗粒最佳制备工艺为：柴胡、枳实、白芍、甘草加 12 倍量 80%乙醇浸泡 30 min,提取 1.5 h,药渣 与生姜、竹茹、蒲公英、延胡索加 8 倍量水,提取 2 次,每次 1.5 h,滤过,合并 3 次滤液,浓缩至膏状,按浓浸膏∶ 木糖醇∶糊精＝1 ∶1 ∶3 进行制粒。结论 该方法操作简单,稳定,可行。 关键词：反流安无糖型混悬颗粒；制备工艺；薄层色谱法；高效液相色谱法 DOI：10.3969/j.issn.1005-5304.2014.05.027 中图分类号：R283.5 文献标识码：A 文章编号：1005-5304(2014)05-0086-05 Quality Study of Free-sugar Suspended Granules of Fanliuan of Different Preparation Process 1 2 2 1 1 1 JIN Yong-xin , GAO Li-hua , GU Xue-yan , ZHANG Rui-tang , MA Xiao , YAO Lin-qing (1.Second People’s Hospital of Gansu Province, Lanzhou 730000, China ；2.Lanzhou University, Lanzhou 730000, China) Abstract ：Objective To compare the quality of Free-sugar Suspended Granules of Fanliuan of different preparation technology, and optimize its preparation process. Methods The color, uniformity, taste and smell of particles of two kinds of extraction process were compared to optimize the proportion of drug, xylitol and dextrin of particle formation process, and dissolubility, size, liquidity of particles were investigated. Bupleuri radix, Aurantii fructus immaturus, Paeoniae radix alba and Rhizoma corydalis were identified by TLC, and paeoniflorin and hesperidin were determined by HPLC to compare the effect of water extraction and alcohol extra