家兔佐剂性关节炎致疼痛前后听觉P300变化.pdfVIP

● 实验研究 ● 家兔佐剂性关节炎致疼痛前后 听觉P300的变化 卢惠苹，张 雷，倪国新 [摘要]目的：探讨家兔佐剂性关节炎致疼痛前后听觉事件相关电位P300成分的变化。方法： 分别记录日本大耳白兔注射弗氏佐剂前，注射弗氏佐剂后第7天、第21天用吗啡止痛前后的听觉P300 和痛阈。结果：家兔注射佐剂后第7天和第21天痛阈下降，听觉P300潜伏期均较正常时明显延长；运 用吗啡止痛治疗后，痛阈上升，潜伏期明显缩短。注射佐剂后第7天P300波幅较正常时明显降低；运用 吗啡止痛治疗后，波幅明显增高。注射佐剂后第21天波幅较第7天明显增高。结论：佐剂性关节炎兔 的听觉P300与疼痛程度密切相关。 [关键词]佐剂性关节炎；P300；波幅；潜伏期；痛阈 of with induced P300inrabbits arthritis Changesauditory adjuvant LU Lei，NIGuoxin Huiping，ZHANG Rehabilitation，Fuzhou2nd China Deptof MunicipalHospital，F“：^D“(350007)，Ft巧iang the ofthe P300underthe of induced [Abstract]Objective：Toexplorechangesauditory statepain inducedarthlritis(AIA)inrabbits．Methods：TheP300and threshold byadjuvant rabbits’auditorypain as Freud’s and wererecordedundertheconditons below：Before respectively adjuvantinjection，before onthe andthe afterFreud’s the aftermorphine 7山day 215’day adjuvantinjection．Results：With injection thresholdlowed，theof P300was onthe7th and21st pain latencyauditory differentiallyprolonged day afterrabbitswere Freud’S withthenormal．After adjuvantcompared curing，pain days injected morphine thresholdincreasedandthe of P300wasshortened．Onthe ofaLl‘ latencyauditory 7”day。theamplitude P300 P300 decreased．Aftercured，itincreased．Theofauditory ditory differentially morphine amplitude onthe was thanthatofthe is correlationbe‘ 21“daysignificantly 7”day．Conclusion：