《Arsenic exposure and glutamateinduced gliotransmitter release from astrocytes》.pdfVIP

NEURAL REGENERATION RESEARCH Volume 7, Issue 31, November 2012 doi:10.3969/j.issn.1673-5374.2012.31.005 [/nrr-2012-qkquanwen.html] Wang Y, Zhao FH, Liao YJ, Jin YP, Sun GF. Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes. Neural Regen Res. 2012;7(31) :2439-2445. Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes**☆ 1, 2 1 3 1 1 Yan Wang , Fenghong Zhao , Yingjun Liao , Yaping Jin , Guifan Sun 1 Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang 110001, Liaoning Province, China 2 Department of Occupational and Environmental Health, School of Public Health, Shenyang Medical College, Shenyang 110034, Liaoning Province, China 3 Department of Physiology, China Medical University, Shenyang 110001, Liaoning Province, China Abstract The present study used cultures of primary astrocytes, isolated from neonatal rats, to verify the Yan Wang☆, M.D., Associate professor, Department of hypothesis that arsenite-induced neurotoxicity can influence neuronal function by altering Occupational and glutamate-induced gliotransmitter release. Primary astrocytes were exposed to 0, 2.5, 5, 10, 20 or Environmental Health, 30 µM arsenite for 24 hours. Cell viability and morphological observations revealed that 5 µM School of Public Health,