《Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function》.pdfVIP

Journal of Geriatric Cardiology (2012): 158− 165 ©2012 JGC All rights reserved; Research Articles • Open Access • Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function 1 2 1 1 1 1 Su-Yan Bian *, Hong-Yang Guo *, Ping Ye , Lei-Ming Luo , Hong-Mei Wu , Wen-Kai Xiao , Li-Ping 1 1 1 Qi , He-Peng Yu , Liu-Fa Duan 1The Second Department of Geriatric Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China 2Departmen of Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China Abstract Objective Both decreased glomerular filtration rate (GFR) and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial. Moreover, data analyzed from a cohort of Chinese women are rare. Our aim was to explore the relationship between GFR and regional arterial stiffness in Chinese women. Methods In this cross-sectional study, we randomly recruited 1131 adult women residents with GFR ≥ 60 mL/min per 1.73 m2 estimated by the Chinese Modification of Diet in Renal Disease equation from three large communities. Central and peripheral arterial stiffness