SPSS估算一级并行米氏消除药物药动学参数的方法.pdf

# 78# H erald ofMedicine Vol12 N o11 January 2007 # 用药指南# SPSS* , (浙江省温州市第二人民医院药剂科, 325000) [ ] 。 Runge2Kutta , 2, ⊿C /⊿t dC /dt, C C C (C + C ) /2; SPSS ( non linear regression)⊿C /⊿ t i i+ 1 i i+ 1 ()。 SPSS 。 SPSS。 [] ; SPSS;; ; [] R9 9. 1 [] A [ ] 100420781( 2007) 0120078203 E stmi a tin gM eth od of th e Ph arm acok in et ic P ar am eter s of D ru g O b ey in g P ar a llel th e F ir st O rder an d M ich aelis2M enten E lmi in a tion SU Yin2fa, BAI Xue2m in (Depa rmt ent of P ha rm a cy, th e Second P eop le sH osp ita l of Wen zhou C ity, Wenzhou 325000, Ch ina ) AB STR AC T O b ectiv e To estmi ate the pharm acok inetic param eters of drug obeying parallel one order and M ichaelis2 Menten elmi ination with bolus intravenous adm inistration. M e th ods Concentration2tmi e data from the smi u lation by four order Runge2Ku tta algorism were converted in to ⊿ C/⊿ t. The d ifferen tial dC/dtwas replaced by ⊿C /⊿t, and concen tration Cwas replaced by harmonious C C or arithm etic mean(C + C ) /2. ⊿C /⊿t w ith C C or (C + C ) /2 data were fitted i i+ 1 i +i 1 i i+ 1 i i+ 1 by nonlinear regression in SPSS software. R esu lt s The pharm acok inetic param eters ob tained from SP SS were exact and reliable. C on c lu sion SPSS is suitable for estmi ating the pharm acokinetic param eters of drug obeying parallel one order and M ichaelis2Menten el