微乳凝胶经皮给药制剂的研究与应用进展.pdfVIP

·综 述 · 微乳凝胶经皮给药制剂的研究与应用进展  谢明华 1 ，葛敏 1 ，高建青 2*(1.杭州市余杭区第一人民医院，杭州 311100 ；2.浙江大学药学院，杭州 310058) 摘要：目的 介绍微乳凝胶经皮给药制剂的研究与应用进展。方法 根据近年来国内外相关文献，对微乳凝胶作为经皮 给药载体的处方筛选、制备、体外释药性能、质量检查、研究应用进展等方面进行介绍。结果 微乳凝胶具有显著增强 药物的经皮渗透能力、降低药物刺激性和延缓药物释放等作用，且更便于给药。结论 微乳凝胶有望成为一种具有重要 应用价值的经皮给药新剂型。 关键词：微乳；凝胶；载体；经皮给药 中图分类号：R943 文献标志码：A 文章编号：1007-7693(2015)06-0764-05 DOI: 10.13748/ki.issn1007-7693.2015.06.032 Progress of Investigation and Application for Microemulsion-based Gels Transdermal Delivery System 1 1 2* XIE Minghua , GE Min , GAO Jianqing (1.The First People’s Hospital of Yuhang District, Hangzhou 311100, China; 2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China) ABSTRACT: OBJECTIVE To introduce the progress of investigation and application for microemulsion-based gels transdermal delivery system. METHODS Reviewed the domestic and international articles, to introduce the prescription screening, preparation, in vitro release, quality checks and the progress of investigation and application for microemulsion-based gels transdermal delivery system. RESULTS Microemulsion-based gels could increase penetration rate, reduce the irritation, extend the drug action time, and use easy. CONCLUSION It is suggested that microemulsion-based gels is a promising carrier for transdermal drug delivery system. KEY WORDS: microemulsion; gel; carrier; transdermal delivery system 微乳凝胶(microemulsion-based gels ，MBGs) 1 微乳凝胶处方的筛选 是将油相、水相、表面活性剂、助表面活性剂所 微乳凝胶处方的筛选包括微乳处方的筛选和 制得的微乳液加入适宜的凝胶基质中形成的透 凝胶基质的筛选。微乳处方的筛选主要是选择合 明、均质、稳定的凝胶网状结构，网状结构中含 适的组分及确定恰当的比例，只要各组分比例恰 有微乳液滴。微乳能增加药物的溶解度和经皮渗 当，混合后搅匀即可形成微乳[2] 。凝胶