新型水杨醛芳胺席夫碱化合物的合成及生物活性.pdfVIP

新型水杨醛．芳胺席夫碱化合物的合成及生物活性 摘要：目的合成并筛选出生物活性较好的新型抗肝片吸虫病化合物。方法以水杨醛为原料合成了15种卤(硝)代水杨醛一 芳胺席夫碱类化合物；通过元素分析、红外光谱及核磁共振氢谱对合成的15种新化合物进行了表征，并测定其对线粒体呼吸 控制率的影响以及线粒体呼吸过程无机磷的变化，以此对化合物的解偶联活性(杀虫活性)进行了评价。结果所合成的大 型的抗肝片吸虫病药物。 关键词：肝片吸虫；卤(硝)代水杨醛．芳胺席夫碱；杀虫活性；氧化磷酸化 中图分类号：R916．41；R162．2文献标识码：A 文章编号：1001—2494(2005)01—0063—04 and ofthenovel Schiffbase Synthesisbiologicalactivity salicylaldehyde-phenylaminecompounds ZHA0 Scienceand Rui2(1．College巧‘ErwiromentalEngineering，Nankai Wen．yanl，NIUXue—pingz”，ZHANG andChemical 010021，China) 300017，China；2．collegeofChemistry Engineering，InnerMongoliaUniversity，Hohhot To andselectnovelderivativesof Schiffbasewith insecticidalas- ABSTRACT：OBJECTIVEsynthesize salicylaldehyde-phenylaminehigh usedto thetitle andnitrationreaction． theFascila was tivityagainst hepatica．METHODSSalieylal synthesizecompoundsbyhalogenation Thestructuresofthe weredetermined andelecmental their activi— compounds byIR，HNMR analysis．Meanwhileuncoupling of determinedwiththeinfluenceonmitoehondrialcontrol thevariation inoxidative ratio(RCR)andinorganicphosphate ly)WI：Ls respiration 1—15werenew resultsshowedthatmostofthemhad uncou— phosphorylation(APi)．RESULTSCompounds compounds．The relativelyhigh and15．CONCLUSION and15 tobe novelfaciolicidesand 4，10 4，10 potential piingactivities，especiallycompound Compound appeared areworthfurther study．