新生儿缺氧缺血性脑病血清酶检测临床意义.pdfVIP

主垦垫压塞旦匡堂!!!!至!旦箜!鲞箜!翅堡!i!!鱼!垫旦翌!坚塑!堕!丝!!!：!!!：!：坠：! ·13· ·论著· 新生儿缺氧缺血性脑病血清酶检测临床意义 李小彩 【摘要】 目的探讨新生儿缺氧缺血性脑病(HIE)血清酶及心肌肌钙蛋白I(cTnI)的变化和临床 意义。方法对120例缺氧缺血性脑病患儿进行血清酶AST、LDH、a—HRDH、CK、CK—MB及cTnI检测， 观察血清酶改变与病情轻重及预后的关系。并对CK—MB和cTnI作治疗前后的对比观察。结果HIE 组血清酶活性及cTnI较对照组明显升高(P0．05)，且中重度组与轻度组间差异有统计学意义(P 0．05)。观察组治疗(2周)前后检查结果差异有统计学意义(P0．05)。CK-MB与cTnI阳性率在治疗 前后均有显著差异。结论 血清酶的检测可作为判断HIE脑损伤程度和预后的敏感指标。cTnI在判断 心肌损伤方面比CK-MB更具灵敏性和特异性。 【关键词】 新生儿；缺氧缺血性脑病；血清酶；心肌肌钙蛋白I Clinical of detectionofserum inneonateswith Ischenmic significanceactivity enzyme hypoxic encepha- LIXiao-cai．PediatricFirst Scienceand lopathy Departmentof AffiliatedHospital，HenanTechnologyuniversity， Luoyang471003，China To the andclinical of detectionofserumcn— 【Abstract】Objective significancesactivity studychange andcardiac neonateswith ischemic The zyme troponinI(cTnI)inhypoxic encephalopathy(HIE)．Methods andcTnIin caseswithHIEweredetected．The ofserum 120 activity enzymeAST，LDH，d—HRDH，CK，CK-MB resultswere withthe ofHIEand andcTnlwereobservedand the compareddegree prognosis．CK-MB compared resultsbeforethetreatwiththatafterthetreat．ResultsThe ofSerum andcTnIinHIE activity enzyme group were thatin themiddle—severeHIE wereob— than normalcontrol obviouslyhigher group(P0．05)．And group thatinmild resultsofdetectionafterthetreatwere lowerin than viouslyhigher group(P0．05)．The obviously model was differencein ratesofCK—MBandcTnIbetweentheresultsbeforethe group．Theresignificant positive treatwiththatafterthetr