普拉睾酮对老年大鼠的促智作用.pdfVIP

实用老年医学 2000 年第 14 卷第 5 期 251 普拉睾酮对老年大鼠的促智作用 祖衡兵 　黄 　霞 　陈生弟 　陈 　明 　陈红专 ( ) 　　【摘要】　目的 　探讨神经甾体普拉睾酮 DHEA 对老年大鼠学习记忆功能的影响。　方法 　采用跳台试验 法与避暗试验法检测各组 SD 大鼠学习记忆功能的变化。　结果 　结果显示 ,DHEA 能增强老年大鼠的被动逃避 ( ) 能力 ,逃避潜伏期延长 ,5min 错误次数减少 , 以中剂量组的学习记忆能力增强最为显著 P 001 。记忆保持功能 ( ) 测试中 ,中剂量组呈现明显的统计学差异 P 005 ,量效关系呈倒“U ”型曲线。　结论 　DHEA 可显著提高老年 大鼠的学习记忆及记忆保持能力 ,DHEA 对老年性智能缺损等具有潜在的临床应用价值。 【关键词】　神经甾体 　普拉睾酮 　老年大鼠 　学习记忆 Cognitionenhancing of dehydroepiandrosterone in the aged rats　Zu Hengbing . Department of Neurology , Jinshan Hospital , Shanghai Medical University 200540 ; Huang Xia , Chen Shengdi . Department of Neurology , Ruijin Hospital , Shanghai Second Medi cal University200025 　Chen Ming , Chen Hongzhuan . Department of Pharmacology , Shanghai Second Medical University 200025 ( ) 【Abstract 】Objective 　To evaluate the effect of dehydroepiandrosterone DHEA on learning and memory in the aged rats. 　Methods 　Stepdown test and stepthrough test were used to measure the function of learning and memory in the aged rats. 　 Results 　The ability of stepdown and stepthrough passive avoidance was markedly increased when DHEA was administrated in traperitoneally. The footshock passive avoidance latency was prolonged and the number of errors in five minutes was greatly de creased ( P 001) . Interestingly ,significant enhancement of memory retention was also observed at midd