染料木素胶囊对骨质疏松症大鼠骨质代谢影响的比较研究_孙纪元.pdfVIP

2003 6 June, 2003 13 　3 CHINESE JOURNAL OF COMPARATIVE MEDICINE Vol.13　No.3 1 1 2 1 1 3 1 孙纪元,谢艳华,施新猷 , 王四旺,缪珊,李勤, 王剑波 (1., 　710033;2.;3.) 　　【】　　, 。　SD 290 , 、、(5 ·k -1)、(1.5m ·k -1 )、 (18 m ·k -1 )、(9 m ·k -1)、(4.5 m ·k -1)。( ), 。8 , 、L2-4, 。　①, 、(P0.01 P0.05);②、 , 4.5 m ·k -1 、9 m ·k -1 (P0.05 P0.01);③ 4.5 m ·k -1 , 18 m ·k -1 , , 9 m ·k -1 。　4.5 ～9 m ·k -1 。 【】　;;;; 【】　R285.5 　【】A　　【】1671-7856(2003)03-0146-04 Comparative Research of Genistein Capsule on Substance of Bone Metabolism in Osteoporosis Rats 1 1 2 1 1 3 1 SUN Ji-yuan , XIE Yan-hua , SHI Xin-you , WANG Si-wan , MIAO Shan , LI Qin , WANG Jian-bo (1.Institute of Materia Medica in Fourth Military Medical University, Xian 7l0033, China; 2.Laboratory Animal Reaserch Center, Fourth Military Medical University;3.Tumor hospital of Shaanxi province) 【Abstract】　Objective　To investi ate the effect of substance of bone metabolism of the enistein capsu1e(GEN)on femur biomechanics and bone mineral density (BMD)in osteoporosis rats.Methods　290 female rats were devided into several roups at random:control, model, GSK(5 ·k -1 ), Nilestriol(1.5m ·k -1 ), GEN of hi h dose(18m ·k -1), medium dose(9m ·k -1 ) and low dose(4.5m ·k -1 ).The rats were sur ically ovariectomized (OVX)or sham-operated (Sham).The rats were sacrificed and some parameters of each side of femur, tibia and lumbar2-4 were determined at different time.Results　1.Nilestriol and GEN of medium dose could slow the wei ht of rats and increase