月桂氮卓酮对阿司匹林乳膏体外释药的影响.pdfVIP

1046 J Bengbu M ed Co l,l O ctober 2010, V o.l 35, N o. 10 [ ] ( 20 10) 10104 603 药 学 , , , [ ] 目的: 方法: , F ranz , 结果: 5% 10% 10. 6% 25. 0% 结论: , H igu chi [ ] [ ] R 97 1. 1 [ ] A E ffects of laccrocap ram on percu tan eou s ab sorption of a sp irin cream W ANG X iu, GU Y azhou, Q IAN J ianghua, WU H uapu (D ep artm ent of Pharm aceutics, B engbuM edical College, BengbuA nhui 2 330 30, China) [ A bstract] O bj ective: T o stu dy the e ffect o f laccrocapram on p ercu taneou s ab sorption o f asp ir in cream across m ice sk in in vitro. M ethods: F lu ids w e re co llected by u sing F ranz d iffu sion cells after p erm eation through the skin o f m ice. A nd the pe r squ are centmi eter s accum ulative p erm eation qu antity, steady pe rcutaneou s speed and pe rm ea tion coe ff ic ient w ere determ ined by ultrav iolet spectroscopy. R esu lts: Steady p ercutaneou s sp eed o f ace tyl salicy lic ac id cream w ith 5% and 10% laccrocapram increased 10. 6% and 25. 0% , resp ectiv ely. Conc lu sion s: D ifferent concentration s of laccrocapram can increasing p erm eation o f acety l sa licylic acid. T he p erm eation from em ulsion base confo rm ed to H iguchi equ ation. [ K ey w ords] asp irin laccrocapram p ercu taneou s ab sorption , 1. 2 方法 1. 2. 1 0. 05 g [ 1] , , 50 m l, 50 m l , , 1 000 g /m l, O /W , , 100. 0050. 00025. 000 12. 5006. 250 , 3. 125 g /m l 276 nm , , ,