泽泻不同溶剂提取物对糖尿病小鼠血糖及血液生化指标的影响.pdfVIP

解放军药学学报 22 6 ! 419! : 2006) : R965 : A 杨新波 , 黄正明 , 陈红艳,魏玉萍, 王建华, 曹文斌 ,耿 淼 ( 100853; 302 100039) : - 1 , 472mg!kg , - 1 0. 5g! kg ; , ; : ;; ; Effectsof Different Solvent Extracts from Alisma Orientalis on Blood Glucose and Biochemical Indicators inDiabeticM ice YANG XinBo , H ANG ZhengM ing , CHEN HongYan,WEIYuPing, WANG JianHua, CAOWenBin , Geng M iao ( Department of Pharm acology, Institute of Geriatrics, ChinesePLA GeneralHospita,l Beijing 100853 China) ( Department of Pharm acy, Hospital 302 ofPLA, Beijing 100039 China) ABSTRACT: Aim To study the effects of different solvent extracts from Alisma Orientalis on blood glucose and bi ochem ical indicators in diabeticm ice. MethodsA lism aOrientaliswere extracted by different solvents: alcohol, li - 1 garine, acetic ether and water. The diabeticmodelwas prepared: by injecting them ice w ith 72mg!kg alloxan. Blood glucose, blood lipids and blood biochem ical indicatorswere determ ined by using Automatic Biochem istry. - 1 The diabetic anmi alswere treatedw ith four kinds of extracts by ig 0. 5g!kg . Results In diabeticm ice, the levels ofblood glucose, triglyceride, total cholesterol, creatinine and ureanitrogen increased significantly. W atersoluble extracts slightly decreased blood glucose. Ethanolsoluble extracts could antagonize thehigh level