糖皮质激素致寻常型天疱疮患者功能失调性子宫出血1例.pdfVIP

33  2 2015  4 华西口腔医学杂志 第 卷 第 期 年 月 •218 • West China Journal of Stomatology Vol.33 No.2 Apr. 2015 [文章编号] 1000-1182(2015)02-0218-03 ·病例报告· 糖皮质激素致寻常型天疱疮患者 功能失调性子宫出血1例 冯慧 罗小波 江潞 陈谦明 口腔疾病研究国家重点实验室 华西口腔医院黏膜病科（四川大学），成都610041 [摘要] 天疱疮是一类严重的、慢性黏膜-皮肤大疱性自身免疫性疾病。临床治疗以系统应用糖皮质激素为主。功能 失调性子宫出血是由下丘脑-垂体-卵巢轴功能失调引起的异常子宫出血。本文报道1例全身应用糖皮质激素后出现功 能失调性子宫出血的寻常型天疱疮患者，并通过回顾文献对糖皮质激素导致功能失调性子宫出血的机制进行了探讨。 [关键词] 糖皮质激素； 寻常型天疱疮； 功能失调性子宫出血 [中图分类号] R 781.6 [文献标志码] B [doi] 10.7518/hxkq.2015.02.024 Patient with pemphigus vulgaris complicated with dysfunctional uterine bleeding upon glucocorticoid usage: a case report Feng Hui, Luo Xiaobo, Jiang Lu, Chen Qianming. (State Key Laboratory of Oral Diseases, Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) [Abstract] Pemphigus is a severe chronic autoimmune mucocutaneous bullous disease. Glucocorticoids are considered as the first line of treatment for this disease. Dysfunctional uterine bleeding is also observed as a result of hypothalamic-pituitary- ovary axis dysfunction. This study reported one female patient with pemphigus vulgaris complicated with dysfunctional uterine bleeding upon systemic glucocorticoid usage. Before this disease was diagnosed, the patient experienced normal menstruation. The mechanism of dysfunctional uterine bleeding triggered by glucocorticoids is elucidated on the basis of case studies and literature review. [Key words] glucocorticoid; pemphigus vulgaris; dysfunctional uterine bleeding 天疱疮（pemphigus ）是一类严重的慢性黏膜-皮 碍了临床上某些患者对该药物的使用。本文报道1例 肤大疱性自身免疫性疾病，严重时可危及患者的生 典型的全身应用糖皮质