唑来膦酸治疗骨转移临床应用新进展.pdf

2 0 0 9 6 1 26 Chin J Lung Cancer, June 2009, Vol.12, No.6 ·685· A093 摘要 关键词 1.3 64 24 39±16% 2 0 24 0 24 [1] (Zoledronic Acid) , 0 24 3.7±2.0 L/h 4 mg 5 n=5 15 1 [2] n=7 药代动力学 34% [ ±SD]403±118ng/mL vs 264±86ng/mL 1. 1 64 AUC10%(378±116ng x h/mL vs 420±218ng x h/ (28 4 )2 4 8 16 mg 5 15 mL) AUC 24