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Tools to identify the men with prostate cancer most appropriate for active surveillance?.pdf
AsianJournalofAndrology(2014)16,(97—98)
◎2014AJA SIMM &SJTU Allrightsreserved1008—682X
La3cu 盘m0J
wvvwasiaandrocom/wwwajandrologycom
OpenAccess
INVlTED RESEARCHHIGHLIGHT
Toolstoidentifythemenwithprostatecancermost
appropriateforactivesurveillance?
RobertH Getzenberg
AsianJournalofAndrology(2014)16,(97—98);doi:104103/1008—682X.122369;publishedonline:16December2013
InthemanuscriptbyIrshadeta1.the thisearlystageprostatecancermode1.Th e
A goaloftheauthorsistoprovideofrapanelof intersectioncontained19genesthatwere
cancerfelicitousforactivesurveillance genes,i.e.,amolecularsignature,whichcan upregulatedinthemousemodelandalso
withgreaterprecisionthanthataffordedto distinguishbetweenmenwithprostatecancer downregulatedintheavailabledatarelated
ustoday.InthemanuscriptbyIrshadeta1. thatcansafelyforgotreatmentandthosethat toaggressweprostatecancers·
theauthorsevaluateanovelsetofgenes wouldbenefitfrom aninterventionaltherapy. To validatethis19geneset,theauthors
associatedwithsenescenceandagingastools In thismanuscript,theauthorsdescribe analyzedthepubliclyavailabledatasetby
thatcan provideguidanceregardingthe prostatecancersaseitherindolent,definedby Tayloreta1.whichcontainsgeneexpression
indolentnatureofanindividualsprostate dictionary.com as,c‘ausinglittleornopain; dataonprostatectomysamplesalongwith
cancerwithvalidationusingbothmRNA inactiveorrelativelybenign,oraggressive. asmallnumberofnorma1adjacenttissues
andprotein analyses.W hileadditional Toaccomplishthisgoalanddevelopnove1 from thesameprostates.Although only
studiesarerequiredtounderstandthefull andadditivemarkers,theauthorsofcusedon asmal1numberofthesamplesf
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