人胃癌组织中MCP-1和CD34的表达及临床意义.pdf

·344‘ 宣墅疸堂塑壁疸堂苤查!Q!!笙兰旦箜!!鲞筮兰塑 doi：10．3969／j．issn．1006-5709．2013．04．015 人胃癌组织中MCP一1和CD34的表达及临床意义 宋军民1，李 杨2，李 琳1，李 岩1 中国医科大学附属盛京医院1．消化内科；2．重症医学科，辽宁沈阳110004 【摘要】 临床病理特征之间的相关性。结果 0．05；P0．05)。结论MCP一1在人胃癌组织的血管生成过程中发挥作用，参与人胃癌的发生和发展。 【关键词1 胃癌；MCP．1；单核细胞趋化蛋白一1；CD34；血管生成 中图分类号：R735．2 文献标识码：A 文章编号：1006—5709(2013)04—0344—04收稿日期：2012—08．30 Theclinical ofMCP-1andCD34 inhuman cancertissue significance expression gastric SONG Yan’ Junminl，LI Linl，LI Yan92，LI of ofIntensive 1．Department Care ofChinaMedicalUniver— Gastroenterology；2．DepartmentUnit，ShengjingHospital 1 sity，Shenyang10004，China To the ofMCP一1andCD34 inthe and 【Abstract】Objectiveclarifysignificance expressiontumorigenesisprogres— sionofhuman cancer．MethodsThe ofMCP一1andCD34wereexamined a— gastric expression by in42human cancerand12 non-tumortissue thecorrelationbetweenMCP·1and nalysis gastric adjacent samples，and microvessel CD34 wellasMCP·1and featureswasalso density(MVD)(calculatedby expression)as clinic叩athologic assessed．ResultsThe ofMCP一1andCD34in cancertissuewas increasedin expression gastric significantly compari— sonwiththatin non-tumor the ofMCP一1was as— adjacent tissue(P0．001；P0．001)，andexpression significantly sociatedwiththe ofCD34in cancer ofMCP一1wascorre— tissue(P0．01)．Moreover，the expression gastric expression lated with node metastasesandthesizeof stage，invasion