电针修复脊髓损伤的途径：Notch信号及内源性干细胞.docVIP

电针脊髓损伤otch信号与内源性干细胞 中国昆明医学院第一附属医院的耿鑫等的一项研究发现，电针可能通过抑制Notch信号通路促进内源性神经干细胞的增殖，进而达到修复损伤脊髓的目的。电针可促进损伤后神经干细胞的增殖，并抑制其向星型胶质细胞分化可抑制脊髓损伤诱导的Notch信号通路的激活。 Article: Electroacupuncture in the repair of spinal cord injury: inhibiting the Notch signaling pathway and promoting neural stem cell proliferation, by Xin Geng, Tao Sun, Jing-hui Li, Ning Zhao, Yong Wang, Hua-lin Yu (Second Department of Neurosurgery, First Affliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China) Geng X, Sun T, Li JH, Zhao N, Wang Y, Yu HL (2015) Electroacupuncture in the repair of spinal cord injury: inhibiting the Notch signaling pathway and promoting neural stem cell proliferation. Neural Regen Res 10(3):394-403. 欲获更多资讯： Neural Regen Res The pathways to spinal cord injury repair by electroacupuncture Xin Geng, the First Affiliated Hospital of Kunming Medical University, China and his colleagues recently found that electroacupuncture can repair spinal cord injury by inhibiting the Notch signaling pathway and promoting the proliferation of endogenous neural stem cells. Strong evidence exists that electroacupunture contributes to the repair of spinal cord injury by promoting the proliferation of endogenous neural stem cells, inhibiting the differentiation of neural stem cells into astrocytes and reducing the formation of fibrous scars. Electroacupuncture can also alter the microenvironment of neural stem cells and influence some important signaling pathways, such as the Notch signaling pathway. Xin Geng et al. found that electroacupuncture after spinal cord injury promoted the proliferation of neural stem cells, inhibited their differentiation into astrocytes, and suppressed the activation of spinal cord injury-induced Notch signaling pathway. This is one of possibly mechanisms underlying spinal cord injury repair by electroacupunture. Article: Electroacupuncture in the repair of spinal cord injury: inhibiting the Notch signaling pathway and promoting neural stem cell proli