CLA作用机理.pptVIP

Other Possible Mechanisms ? adipocyte apoptosis Tsuboyama-Kasaoka, 2000; Evans et al., 2000 Alteration of PPAR activity PPAR: enzyme involved in the regulation of adipocyte differentiation Moya-Camarena et al., 1999 * Possible Mechanisms of Action Stomach Small Intestine Dietary Fat (TG, FFA) Pancreatic Lipase TG ? FFA Chylomicron TG TG TG TG Adipocyte TG LPL TG TG TG CLA CPT ?-oxidation Energy Muscle Cell Mitochondria FFA CLA Destination of TG ? Dietary fat enters the stomach in the form of triglycerides (TG) or free fatty acids (FFA). The fats enter the small intestine where the TGs are broken down into FFA by the enzyme pancreatic lipase. The FFA are then incorporated into chylmicrons as TGs. During a fed state, the chylomicrons travel through the lympatic system delivering TG to adipocytes (fat cells) in the body. When the chylomicron reaches an adipocyte the enzyme, lipoprotein lipase (LPL), facilitates the transport of the TG from the chylomicron into the adipocyte. TG are then stored in the adipocyte. When we need energy we break down the stored TG in the adipocytes. The FFA from these TG then travel to a cell’s mitochondria (in this diagram we are using a muscle cell as the example) the FFA are transported across the mitochondrial membrane by the enzyme carnitine palmityltransferase (CPT). Once inside the mitochondria the FFA undergoes beta-oxidation and produces energy. So far research has shown that CLA sffect this cycle in at least two key areas: Studies have shown that CLA decreases the activity of LPL. This means that the adipocytes are not able to take up and store as much TG as they would without CLA. Therefore the adipocytes are smaller in size. Studies have shown that CLA supplementation increases the activity of CPT and also increases mitochondrial energy. Therefore it is possible that stored TG are being broken down and transported more rapidly by CPT into the mitochondria for energy production. These two known mechanisms can decreas