西咪替丁相关的药物相互作用汇总分析.pdfVIP

药物与临床 Drugs and Clinic 西咪替丁相关的药物相互作用汇总分析 李牧，刘治军* 北京医院药学部，北京 100730 [摘要] 目的：总结西咪替丁相关的药物相互作用，评价其药物相互作用的临床意义，供临床参考。方法：以 “西咪替丁+药物 相互作用”作为检索策略，通过检索Pub M ed数据库，汇总到20 13年12月之前所有西咪替丁相关的药物相互作用研究。结果： 共检索到符合入选标准的282篇研究(含个案报道、临床研究等) ，涉及到81个西药与西咪替丁的相互作用研究。其中具有临床 意义的药物相互作用(避免合用和谨慎合用)共15对，结论：从 目前的文献综述和分析来看，除15对药物相互作用外，绝大多数 的西咪替丁相关的药物相互作用没有临床意义，可以合用而无需调整剂量。临床药师在为临床提供建议、点评处方和医嘱审核 时不要高估西咪替丁相关的药物相互作用。 [关键词] 西咪替丁；药物相互作用；合理用药 [中图分类号] R961 [文献标识码]　A [文章编号]　1672-2809(2015)02-0019-07 A Review of Cimetidine Related Drug Interactions * LI Mu, LIU Zhi-jun Department of pharmacy, Beij ing Hospital, Beij ing 100730, China [Abstract] Obj ective: To summarize cimetidine related drug interactions and evaluate the clinical significance. Methods: Articles were retrieved in PubMed with ‘cimetidine + drug interactions ’, cimetidine related drug interactions before OCT 2013 were summarized. Results: There were 282 articles of drug interaction and 81 pairs of drug interaction meet inclusion criteria. Only 15 interactions should be avoided or used with precaution. Conclusion: Based on current literature review and analysis, Most of the cimetidine related drug interactions were none-clinical significant except for the 15 interactions, which could be used without dosage adjustment. Clinical pharmacists should not overestimate cimetidine related drug interactions when they were offering professional advice to the doctors, conducting the prescription comment or reviewing medical orders. [Key words] Cimetidine; Drug Interaction; Rational Use of Drug 西咪替丁是临床常见的组胺H2受体拮抗剂 素P4 50 酶(C Y P) 亚铁血红素部分的配体非选择性 (H RA) ，作为抑酸药主要用于消化道溃 的结合 ，引起酶活性障碍。由于每个C Y P 同功酶 2 疡、反流性食管炎的治疗，特别是睡前服用质子泵 都有亚铁血红素配体 ，因此西咪