还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝炎疗效观察.pdfVIP

还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精 性肝炎疗效观察 莫 　晨 ,黄燕苹 ,陕海丽 ,吴小娥 ,刘 　名 ,徐铭宝 # (武警总医院干部病房二科 ,北京市 　100039) 中图分类号 　R975 + 5　　　文献标识码 　B 　　　文章编号 　1672 - 2 124 (20 10) 02 - 0 163 - 02 摘 　要 　目的:观察还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝炎的临床疗效 。方法 : 60例酒精性肝炎患者均戒酒 ,随机 分为治疗组 32例和对照组 28例 。治疗组给予还原型谷胱甘肽联合多烯磷脂酰胆碱静脉滴注 ,对照组单独给予多烯磷脂酰胆碱 静脉滴注 ,疗程均为 4 周 。结果 :两组患者治疗后临床症状 、体征 、实验室检查及彩超检查结果均有一定程度的改善 ,其中治疗组 疗效优于对照组 ,两组疗效比较差异有统计学意义 。结论 :还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝炎疗效满意 ,无明 显不良反应 ,值得临床推广使用 。 关键词 　还原型谷胱甘肽 ; 多烯磷脂酰胆碱 ; 酒精性肝炎 ; 酒精性肝病 Therapeutic Eff icacy of Reduced Gluta th ion e Com b ined w ith Polyene Pho spha tidy lcholine for A lcoholic Hepa titis MO Chen , HUAN G Yanp ing, SHAN H a ili, WU X iaoe, L IU M ing, XU M ingbao# ( Second W ard for Sen ior O fficers, General Ho sp ita l of Ch ine se A rm ed Po lice Force s, B eij ing, 100039 , Ch ina) A BSTRACT 　OBJECT IV E: To evaluate the clin ical therap eu tic efficacy of reduced glu tath ione com b ined w ith po lyene p ho sp hatidylcho line for p atien ts w ith alcoho lic hep atitis. M ETHOD S: A total 60 p atien ts w ith alcoho lic hep atitis who had been ab stained from w ine were random ly a ssigned to either trial group ( n = 32) treated w ith reduced glu tath ione p lu s po lyene p ho sp hatidylcho line ( iv gtt) for 4 week s or con tro l group ( n = 28 ) treated w ith po lyene p ho sp hatidylcho line alone ( iv gtt) for 4 week s. RESUL TS: C lin ical symp tom s and sign s, laboratory exam ination and B - u ltro sound re su lts were all imp roved in both group s, e sp ecially in the trial group and sign ifican t difference s were noted between the two group s ( P 005 ) . CONCLU SION : R educed glu tath ione comb ined w ith po lyene p ho sp hatidylcho line is safe and effective for alcoho lic hep atitis and hence is worthy of clin ical app lication. KEY W O RD S　R educed glu tath ione; Po lyene p ho sp hatidylcho