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232 2010 31 2 A dv Card iovasc D is, M arch 2010, Vol 31, N o 2 subjects[ J]. J T hromb H aemos,t 2005, 3( 4): 662-664. of structural remodeli g[ J] . C irc J, 2004, 68( 4) : 321-327. [ 9] G ree D, Foiles N, Cha C, et al. Elevated fibri oge levels a d subseque t sub- [ 18] U emura T, K aik itaK, Y amabeH, et al. Cha ges i plasma vo W illebra d fac- cli ical atheroscleros is: the CARD IA Study[ J]. A therosclerosis, 2009, 202( 2) :