临床试验中的天然产物抗菌和抗真菌药物.pdfVIP

236 A cta Pharm aceutica S in ica 2007, 42( 3): 236- 244 : 1 1 1* 2* * 2 韩 力 , 郑 丹, 黄学石 , 庾石山 , 梁晓天 ( 1. , 110001; 2. , 100050) : 70% , 1998 2005 1998 : ; ; ; : R916. 693; 978. 5 : A : 05 13- 4870( 2007) 03- 0236- 09 Natural products in clinical trials: antibacterial and antifungal agents 1 1 1* 2* * 2 HAN L i, ZHENG Dan , HUANG Xuehi , YU Sh ihan , LIANG X iaotian (1. School of P harm aceuticalSciences, ChinaM edical University, Shenyang 110001, China; 2. Institute of MateriaM ed ica, Chinese cademy of M ed icalS ciences and P eking UnionM ed ical College, Beij ing 100050, China) Abstract: N atural product have played an mi portant role in drug di covery. T oday, therapeutic from natural orig in count for about 70% of the worldw ide hum an therapeutic ale . For antiin fective treatm ent even h igher f igure are reported. Th i rev iew de cribe antibacterial and antifungal natural product , em iynthetic natural product and natural product derived compound undergo ing clin ical evaluation or reg i tration from 1998 to end of 2005. In addition, natural product derived drug launched ince 1998 are al o d i cu ed in thi rev iew. K ey words: clinical trail ; natural product ; antibacteria;l antifungal ( natural product, NP ) 2003 , [ 6] Newm an NP [ 1~ 3] 10 ~ 15 X , NP NMR , , , NP 2000~ 2002 , [ 7]