姜黄素对缺血再灌注大鼠脑组织SOD_MDA和亚硝酸盐含量的影响_石晶.pdfVIP

386 Acad J Sec Mil Med Univ1999 Jun; 20(6) SOD MDA, △ ▲ 石　晶　陶　沂 　胡晋红　田亚平 目的:(MDA)(SOD) , 方法:4 ( 30 min , 15 min) , , (20 40 / ) 30 SOD MDA mg kg min 结果:30 min 15 min ,M DA , SOD 结论: ; ;; ;; 651. 12 R Effects of curcuminoncontentsof SOD MDAandnitriteinthebrain, of cerebral ischemiareperfusion rats Shi Jing Tao Yi, , u Jinhong Tian Yaping Department of Pharmacy Changhai ospital, ( , , Second Military Medical University Shanghai, , 200433) ABSTRACTObjective: To investigate the protective mechanism of curcumin on ischemia reperfusion in- jury in rats. Methods: The 4 vessel occlusion rat model was used, and the contents of malonaldehyde (MDA) , nitrite and SOD in brain tissue were detected after 30 min ischemia and 15 min reperfusion with spectrophotometry and chemoluminescence respectively. Curcumin was given ( 20 or 40 mg/kg) intraperi- toneally 30 min before ischemia. Results: The contents of MDA and nitrite in the brain were significantly increased after ischemiaand reperfusion whilethis increase was inhibited in curcumin treated groups The, . activity of SOD in brain of curcumin groups was elevated Conclusion Theprotective effect of curcumin in. : cerebral ischemia reperfusion injury might berelated to its inhibiting activity on radical generation and rad- ical eleminating action. ; ; ; ; ; KEY ORDS curcumin cerebral ischemia reperfusion injury lipid peroxide nitric oxide superoxide dismutase [Acad J Sec Mil Med Univ, 1999, 20(6) : 386387] 1.3　大鼠4 血管结扎脑缺血再灌注模型　 (cur-