锯缘青蟹一种新的阴离子抗菌肽scygonadin及其基因的分离与鉴定.pdf

Characterization, Genomic Organization and Expression Analysis of a Novel Anionic Antimicrobial Peptide, Scygonadin, Isolated from Scylla serrata A Dissertation Submitted to the Graduate School of Xiamen University in Fulfillment of the Requirements for the Degree of Doctor of Philosophy, by Huang Wen-Shu Supervisors: Prof . Li Shao-Jing Wang Ke-Jian Department of Oceanography, Xiamen University Xiamen, China, August 2006 目录 目录 第一章 绪论··························································································· 1 第一节 抗菌肽的分类········································································· 2 1.1 阳离子抗菌肽········································································· 2 1.2 阴离子抗菌肽········································································· 5 1.3 源自神经肽前体的抗菌肽······················································· 9 1.4 芳香二肽················································································ 9 1.5 氧结合蛋白及其他大蛋白质裂解肽段······································ 10 第二节 抗菌肽的作用机理·································································· 10 2.1 跨膜孔的形成机制·································································· 11 2.2 细胞内的杀菌机制·································································· 13 第三节 甲壳动物抗菌肽研究进展························································ 15 3.1 甲壳动物宿主防御体系··························································· 15 3.2 甲壳动物的相关抗菌活性研究················································· 18 3.3 甲壳动物抗菌肽研究进展·························