5分子间和分子内的相互作用力.ppt

Structure and Properties of Water Because of Hydrogen Bonding... Water has a uniquely high specific heat (1 cal/g°C) and a uniquely high heat of vaporization (541.6 cal/g). Thermal regulation of the climate. Absorbs heat during the day (vaporization of water) Warms the earth during the night (dew etc.). The density of solid water is less than liquid water. Very unusual. This allows life to exist in our oceans and lakes. The Concentration of Solute Particles # Nonelectrolytes： One mole of a nonelectrolyte produces one mole of solute particles csolute particles= c # Electrolytes: Exist as ions in solution Provide more than one mole of particles per mole of solute dissolved cs.p.=i·c, i is the moles of solute particles per mole solute Questions 习题 P193: 4,6,8,12,14 P168: 7,8,10,15 THE END Dispersion forces operate between all molecules. Drug Interaction: Ligand-Macromolecule Complex A majority of pharmacologic responses are mediated through receptors (note exceptions: such as anesthetics and some diuretics function based on their physical properties alone) mobile drug + cellular receptor -- drug-receptor complex neurotransmitters, hormones, misc. extra/intracellular mediators signal transduction (protein-protein interactions important) numerous enzyme-substrate complexes methotrexate-dihydrofolate reductase (DHFR) antibody-antigen interactionstranscriptional regulationothers.... Intermolecular Forces Exist Between Molecules Intermolecular forces draw molecules together; kinetic energy drives them apart The Origination of Intermolecular Forces Properties of Solutions Colligative Properties 1. lowering the Vapor Pressure 2. Boiling-Point Elevation 3. Freezing-Point Depression 4. Osmosis Factors Affecting Solubility Dynamic equilibrium Factors Affecting Solubility ---The solution process Solvation Hydration 1. Solute-solute interactions 2. Solvent-solvent interactions 2. Solute-solvent interactions ---Solution Formation Energy Changes Spon