《Hierarchically Clustered HMM for Protein Sequence Motif Extraction with Variable Length》.pdfVIP
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TSINGHUASCIENCEANDTECHNOLOGY
ISSN1007-021408/10
pp635-647
Volume 2014
19,Number6,December
ClusteredHMMforProtein Motif
Hierarchically Sequence
withVariable
Length
CodyHudson,BernardChen+,and Che
Dongsheng
Abstract:Proteinmotifsextractionisan fieldofbioinformaticssinceitsrelevancetothe
sequence important
structural are
relatedtothis themotifswithinthesame
analysis.Twomajorproblems field:(1)searching protein
awindowsizefor
themotifssearch.Thiswork the Clustered
family;and(2)assuming proposesHierarchically
HiddenMarkov thebehaviorandstructureof intermsof
Model(HC—HMM)approach,which
represents proteins
aHiddenMarkovModelchain
and clusterseachchain distancebetweentwo
hierarchically byminimizing given
chains’structureandbehavior.ItiswellknownthatHMMcanbeutilizedfor for
onHiddenMarkovModelsthemselvesare studied.Inthis ahierarchical
clustering rarely paper,wedeveloped
based forHMMstodiscover motifsthattranscendboundarieswithno
clusteringalgorithm proteinsequence family
onthe ofthemotif。This examinestheeffectivenessofthis formotif
assumptionlength papercarefully approach
extractionon2593 thatsharenomorethan motifsare
proteins
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