《Leveraging Metabolomics to Assess the Next Generation of Temozolomidebased Therapeutic Approaches for Glioblastomas》.pdfVIP
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GenomicsProteomicsBioinformatics1l206
GenomiesProteomicsBioinformaties
www.elsevier,com/locate/gpb
Ⅵ—vw.seiencedirect.corn
REVIEW
MetabolomicstoAssesstheNext
Leveraging
ofTemozolomide--based
Approaches
Therapeutic
forGlioblastomas
2
Patrick.DenisSt.Coeur Touaibia
1,Mohamed 1,MiroslavaCuperlovic.Culf
1-4
PierMorin
Jr
de EIA
Moncton,Morn’ton,NB3E9,Canada
‘DepartmentofChemisto,andBiochemistry,Universitd
2
EIA
NationalResearchCouncilCanada,Monc’ton,NB7RI,Canada
ol
Received30 2013:revised29March 13 2013
January 2013:acceptedApril
Availableonline1 June20l 3
KEYWORDS multiformethemostcommonadult tumorofthecen—
AbstractGlioblastomafGBM)is primary
tra】nervous currentstandardofcarefor involvesacombination
Glioblastoma system。The glioblastomapatients
multiforme;
of and withthe temozolomide.Severalmech—
chemotherapy agent
Temozolomide; surgery,radiotherapy alkylating
anisms theinherentand temozolomideresistancehavebeenidentifiedandcon.
cascades; underlying acquired
Signaling
Cancer tributetotreatmentfailure identification
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