Cleavable linkers in chemical biology.pdfVIP

Bioorganic Medicinal Chemistry 20 (2012) 571–582 Contents lists available at ScienceDirect Bioorganic Medicinal Chemistry journal homepage: www.else /locate/bmc Cleavable linkers in chemical biology Geoffray Leriche, Louise Chisholm, Alain Wagner ⇑ Laboratory of Functional Chemo-Systems UMR 7199, 74 Route du Rhin, 67401 Illkirch-Graffenstaden, France a r t i c l e i n f o a b s t r a c t Article history: Interest in cleavable linkers is growing due to the rapid development and expansion of chemical biology. Available online 30 July 2011 The chemical constrains imposed by the biological conditions cause significant challenges for organic chemists. In this review we will present an overview of the cleavable linkers used in chemical biology Keywords: classified according to their cleavage conditions by enzymes, nucleophilic/basic reagents, reducing Cleavable linker agents, photo-irradiation, electrophilic/acidic reagents, organometallic and metal reagents, oxidizing Chemical biology reagents. Proteomic 2011 Published by Elsevier Ltd. ABPP Biocompatible 1. Introduction the specific application of the linker, for example often the objec-