Main-chain imidazolium oligomer material as a selective biomimetic.pdf

Biomaterials 33 (2012) 8625e8631 Contents lists available at SciVerse ScienceDirect Biomaterials journal homepage: www.elsevi /locate/biomaterials Main-chain imidazolium oligomer material as a selective biomimetic antimicrobial agent a,1 b,1 a a a b, c, * Lihong Liu , Yuan Huang , Siti Nurhanna Riduan , Shujun Gao , Yiyan Yang , Weimin Fan , Yugen Zhang a, * a Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore b State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affi liated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, PR.China c Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA a r t i c l e i n f o a b s t r a c t Article history: Human health has been challenged by multi-drug-resistant microorganisms for several decades. Herein, Received 29 May 2012 we have developed a main-chain imidazolium oligomer (IBN-1) material to combat broad spectrum of Accepted 1 August 2012 pathogenic strains, including drug-resistant Klebsiella pneumoniae, Vancomycin-resistant enterococcus, Available online 16 August 2012 Methicillin-resistant Staphylococcus aureus and fluconazole-resistant yeast Cryptococcus neoformans,