A novelty seeking phenotype is related to chronic HPA activity reflected by hair cortisol .pdfVIP

Physiology Behavior 104 (2011) 291–295 Contents lists available at ScienceDirect Physiology Behavior journal homepage: www. elsevi /locate/phb A novelty seeking phenotype is related to chronic hypothalamic-pituitary-adrenal activity reflected by hair cortisol Mark L. Laudenslager a,⁎, Matthew J. Jorgensen b, Rachel Grzywa a, Lynn A. Fairbanks c a Department of Psychiatry, University of Colorado at Denver School of Medicine, Denver CO 80220, United States b Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem NC, United States c Department of Psychiatry Biobehavioral Sciences, Semel Institute, University of California at Los Angeles, Los Angeles CA 90095, United States a r t i c l e i n f o a b s t r a c t Article history: Reduced hypothalamic pituitary adrenal (HPA) activity is associated with greater novelty seeking in humans. Received 30 August 2010 Hair cortisol represents an integrated proxy measure of total cortisol production/release over an extended Received in revised form 1 March 2011 period of time and may be a valuable tool for tracking the HPA system. Sampling approaches (collection of Accepted 2 March 2011 blood, saliva, urine, or feces) for socially housed nonhuman primates present a number of technical challenges for collection particularly when repeated sampling is necessary. Herein we describe a relationship between Keywords: