《《aiming for ideal synthesis》.pdfVIP

/joc Aiming for the Ideal Synthesis Tanja Gaich and Phil S. Baran* Department of Chemistry, The Scripps Research Institute, 10550North TorreyPines Road, 92037La Jolla, California pbaran@ Received April 8, 2010 The field of total synthesis has a rich history and a vibrant future. Landmark advances and revolutionary strides in the logic of synthesis have put the practicing chemist in the enviable position of being able to create nearly any molecule with enough time and effort. The stage is now set for organic chemists to aim for “ideality” in the way molecules are synthesized. This perspective presents a simple and informative definition of “ideality” and demonstrates its use during the self-evaluation of several syntheses from our laboratory. Introduction This prescient statement truly encompassed and epito- 3 mized the “economies” of synthesis design many years In the 20th century, the art and science of complex natural 4 5 6 before the ideas of atom, step, and redox-economy were product total synthesis defined the frontiers of organic 1 formally galvanized. Many factors may be