右美托咪定对体外循环冠脉搭桥患者心肌缺血再灌注损伤的保护作用.pdf

Abstract abilitiesofDexmedetomidine objective：The ischemia protection againstmyocardialreperfusion in injurycoronaryarterybypass dectionthe graft(CABG)patients，wereinvestigatedby concentrationof andIL一10． T，TNF-a changestroponinI，troponin underwent was dividedinto4 Methods：Eightypatients coronaryarterybypassgraft randomly groups Dex andthecontrol intheDex received0．5 1，2，3 group(Con)．Thepatients groups pg／kg(Dex1)， 0．75 1．0 Dexmedetomidinebefore gg／kg(Dex2)andgg／kg(Dex3)of cardiopulmonarybypass．The fractionwas monitored hand24h ejection pre—anesthesia，post—CBP,6 postsurgery．Bloodsamples wereobtaiedfordetectionoftheconcentrationof T，TNF-。LandIL．10 changestroponinI，troponin by ABC-ELISAorELISA．ThederiveddataWas theSPSS16．0 for preparedby sofrwaethemathematical sta“sties Results：InthecontrolandDex fractionwasreducedandtheconcentrationof group，theejection andIL·10increased withthecontrol 廿oponin T，TNF-a I，troponin evidently．Comparedgroup， Dexmedetomidine the treatment andreducedtheconcentrationof improvedejection仔action troponin IL·10 T，TNF—c【and I，troponin significantly theconcentrat